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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/12842
Title: 
The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
Author(s): 
Institution: 
  • Universidade Estadual Paulista (UNESP)
  • Northwestern University (NU)
  • Santa Casa Faculty of Medicine of São Paulo
ISSN: 
0102-8650
Sponsorship: 
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Sponsorship Process Number: 
FAPESP: 10/08562-0
Abstract: 
PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.
Issue Date: 
1-Jan-2013
Citation: 
Acta Cirúrgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 05-09, 2013.
Time Duration: 
05-09
Publisher: 
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Keywords: 
  • Acute Kidney Injury
  • Fluid Therapy
  • Colloids
  • Hetastarch
  • Rats
Source: 
http://dx.doi.org/10.1590/S0102-86502013000100002
URI: 
http://hdl.handle.net/11449/12842
Access Rights: 
Acesso aberto
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/12842
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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