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http://acervodigital.unesp.br/handle/11449/156- Title:
- Desenvolvimento e caracterização de nanocápsulas de poli (L-lactídeo) contendo benzocaína
- Development and characterization of poli (L-lactide) nanocapsules containing benzocaine
- Universidade Estadual Paulista (UNESP)
- Universidade Estadual de Campinas (UNICAMP)
- Universidade Federal do ABC (UFABC)
- 0100-4042
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- Fundação para o Desenvolvimento da UNESP (FUNDUNESP)
- In this paper we describe the preparation poly (L-lactide) (PLA) nanocapsules as a drug delivery system for the local anesthetic benzocaine. The characterization and in vitro release properties of the system were investigated. The characterization results showed a polydispersity index of 0.14, an average diameter of 190.1± 3 nm, zeta potential of -38.5 mV and an entrapment efficiency of 73%. The release profile of Benzocaine loaded in PLA nanocapsules showed a significant different behavior than that of the pure anesthetic in solution. This study is important to characterize a drug release system using benzocaine for application in pain treatment.
- 1-Jan-2010
- Química Nova. Sociedade Brasileira de Química, v. 33, n. 1, p. 65-69, 2010.
- 65-69
- Sociedade Brasileira de Química
- local anesthesic
- PLA nanocapsules
- drug release
- http://dx.doi.org/10.1590/S0100-40422010000100013
- http://hdl.handle.net/11449/156
- Acesso aberto
- outro
- http://repositorio.unesp.br/handle/11449/156
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