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- Caracterização físico-química de complexo de inclusão entre hidroximetilnitrofurazona e hidroxipropil-beta-ciclodextrina
- Physico-chemical characterization of inclusion complex between hydroxymethylnitrofurazone and hydroxypropyl-beta-cyclodextrin
- Universidade Estadual Paulista (UNESP)
- Universidade de São Paulo (USP)
- Universidade Estadual de Campinas (UNICAMP)
- 0100-4042
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
- Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) can be used as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize the inclusion complex between NFOH and HP-beta-CD. The rate of NFOH release decreases after complexation and thermodynamic parameters from the solubility isotherm studies revealed that a stable complex is formed (deltaGº= 1.7 kJ/mol). This study focuses on the physico-chemical characterization of a drug-delivery formulation that comes out as a potentially new therapeutic option for Chagas disease treatment.
- 1-Jan-2008
- Química Nova. Sociedade Brasileira de Química, v. 31, n. 2, p. 290-295, 2008.
- 290-295
- Sociedade Brasileira de Química
- hydroxymethylnitrofurazone
- cyclodextrin
- inclusion complex
- http://dx.doi.org/10.1590/S0100-40422008000200019
- http://hdl.handle.net/11449/157
- Acesso aberto
- outro
- http://repositorio.unesp.br/handle/11449/157
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