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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/16044
Title: 
Different Molecular Weight Chitosan-Based Membranes for Tissue Regeneration
Author(s): 
Institution: 
  • Universidade Estadual Paulista (UNESP)
  • Universidade de São Paulo (USP)
ISSN: 
1996-1944
Abstract: 
Natural polymers, such as chitosan, obtained from chitin, are been widely studied for use in the tissue regeneration field. This study established a protocol to attain membranes made from this biopolymer, consisting of high or low molecular weight chitosan. The biocompatibility of these membranes was histologically evaluated, comparing them to collagen membrane surgically implanted in rat subcutaneous tissue. Fifteen Holtzmann rats were divided in three experimental groups: High and Low Molecular Weight Chitosan membranes (HMWC and LMWC) and Collagen membranes (C-control group); each of them with three experimental periods: 7, 15 and 30 days. As a result, after the seven days evaluation, the membranes were present and associated with a variable degree of inflammation, and after the 15 and 30 days evaluations, the membranes were absent in all groups. It is concluded that the chitosan-based membranes were successfully attained and presented comparable resorption times to collagen membranes.
Issue Date: 
1-Feb-2011
Citation: 
Materials. Basel: Mdpi Ag, v. 4, n. 2, p. 380-389, 2011.
Time Duration: 
380-389
Publisher: 
Mdpi Ag
Keywords: 
  • chitosan
  • tissue regeneration
  • chitosan hydrochloride
  • membrane
Source: 
http://dx.doi.org/10.3390/ma4020380
URI: 
http://hdl.handle.net/11449/16044
Access Rights: 
Acesso aberto
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/16044
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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