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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/40907
Title: 
Chronic Suppurative Otitis Media in Cleft Palate: Microorganism Etiology and Susceptibilities
Author(s): 
Institution: 
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
  • Instituto Lauro de Souza Lima (ILSL)
ISSN: 
1055-6656
Abstract: 
Objective: To investigate the microbial etiology of suppurative chronic otitis media (SCOM) in patients with complete cleft lip and palate and isolated cleft palate and to determine the sensitivity of isolated microorganisms to antibiotics by drug diffusion from impregnated discs in agar and the minimum inhibitory concentration of each drug to these microorganisms by drug dilution in agar.Design/Patients: Effusion samples of SCOM obtained from 40 patients with cleft lip and palate registered at the Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, at Bauru, Brazil, were bacteriologically analyzed by cultures. The isolated bacteria were submitted to an in vitro susceptibility test to clinically used drugs.Results: Positive cultures were obtained in 100% of studied cases. Among the 57 strains observed, the most frequent were Pseudomonas aeruginosa (35%), Staphylococcus aureus (15.5%), Enterococcus faecalis (14%), and Proteus mirabilis (12%). The frequency of Gram-negative bacilli (enterobacteriaceae and nonfermentative bacilli) was 67%. Pseudomonas aeruginosa presented the highest sensitivity to ciprofloxacin, and enterobacteriaceae exhibited the highest sensitivity to gentamicin. The strains of S. aureus and E. faecalis presented the highest sensitivity to imipenem and sulfamethoxazole/trimethoprim, respectively.Conclusion: Patients with cleft lip and palate presenting with SCOM exhibited 100% positive cultures, with the highest frequency of Pseudomonas and enterobacteriaceae. With regard to the action of antibiotics, imipenem was effective against the four species of isolated microorganisms, followed by ciprofloxacin, which was effective against 75% of isolated species.
Issue Date: 
1-Sep-2009
Citation: 
Cleft Palate-craniofacial Journal. Lawrence: Alliance Communications Group Division Allen Press, v. 46, n. 5, p. 461-467, 2009.
Time Duration: 
461-467
Publisher: 
Alliance Communications Group Division Allen Press
Keywords: 
  • cleft lip
  • cleft palate
  • drug susceptibility
  • microbiology
  • suppurative chronic otitis media
Source: 
http://dx.doi.org/10.1597/08-144.1
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/40907
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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