Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/42629
- Title:
- Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax
- Storti-Melo, Luciane Moreno
- Costa, Daniela Reis da
- Souza-Neiras, Wanessa Christina
- Cassiano, Gustavo Capatti
- D'Almeida Couto, Vanja Suely Calvosa
- Povoa, Marinete Marins
- Soares, Irene da Silva
- Carvalho, Luzia Helena de
- Arevalo-Herrera, Myrian
- Herrera, Socrates
- Baptista Rossit, Andrea Regina
- Cordeiro, Jose Antonio
- Mattos, Luiz Carlos de
- Machado, Ricardo Luiz Dantas
- Universidade Federal de Sergipe (UFS)
- Faculdade de Medicina de São José do Rio Preto (FAMERP)
- Universidade Federal do Triângulo Mineiro (UFTM)
- Universidade Estadual Paulista (UNESP)
- Nucleo Estadual Amapa CRDT
- Secretaria Vigilancia Saude
- Universidade de São Paulo (USP)
- Fundação Oswaldo Cruz
- Univ Valle
- Universidade Federal Fluminense (UFF)
- 0001-706X
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- COLCIENCIAS
- Ministry of Social Protection
- National Institute of Allergy and Infectious Diseases (NIAID)
- FAPESP: 02/09546-1
- FAPESP: 06/09546-1
- CNPq: 302353/03-8
- CNPq: 410405/2006-0
- COLCIENCIAS: 1106-04-16489)
- Ministry of Social Protection: 2304-04-19524
- Ministry of Social Protection: 253-2005
- National Institute of Allergy and Infectious Diseases (NIAID): 49486/TMRC
- We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HILA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the H1A-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria. (C) 2011 Elsevier B.V. All rights reserved.
- 1-Feb-2012
- Acta Tropica. Amsterdam: Elsevier B.V., v. 121, n. 2, p. 152-155, 2012.
- 152-155
- Elsevier B.V.
- Plasmodium vivax
- HLA-DRB1
- Antibody response
- http://dx.doi.org/10.1016/j.actatropica.2011.10.009
- Acesso aberto
- outro
- http://repositorio.unesp.br/handle/11449/42629
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.