Desnaturação de oxihemoglobinas humanas A, A2 e S pelo metodo de tampão isopropanol

Naoum, P. C.; Teixeira, U. A.; Machado, P. E. de Abreu; Michelin, O. C.

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/63442

Title:

Desnaturação de oxihemoglobinas humanas A, A2 e S pelo metodo de tampão isopropanol

Other Titles:

The denaturation of human oxyhaemoglobin A, A2 and S by isopropanol/buffer method

Author(s):

Institution:

Universidade Estadual Paulista (UNESP)

ISSN:

0100-879X

Abstract:

Human oxyhaemoglobin A and A2 from normal individuals and oxyhaemoglobin S from patients with sickle cell anaemia and sickle cell trait were studied using Isopropanol/buffer method at 37°C and 40°C. Hb S was less stable than Hb A, whereas Hb A2 was considerably more stable than either. Denaturation of Hb S was dependent on temperature and its concentration. Between the patients with sickle cell trait it was not possible to verify the influence of the concentration probably due to the small range used (from 38% to 44%).

Issue Date:

1-Dec-1978

Citation:

Brazilian Journal of Medical and Biological Research, v. 11, n. 4-5, p. 241-244, 1978.

Time Duration:

241-244

Keywords:

2 propanol
hemoglobin a
hemoglobin a2
blood and hemopoietic system
human cell
sickle cell anemia
sickle cell trait
1-Propanol
Blood Protein Electrophoresis
Buffers
Heat
Hemoglobin A
Hemoglobin A2
Hemoglobin, Sickle
Human
Oxyhemoglobins
Protein Denaturation

URI:

Access Rights:

Acesso restrito

Type:

outro

Source:

http://repositorio.unesp.br/handle/11449/63442

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