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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/74698
Title: 
Reduced in vitro immune response on titania nanotube arrays compared to titanium surface
Author(s): 
Institution: 
  • Harvard University
  • Universidade Estadual Paulista (UNESP)
  • Colorado State University
ISSN: 
  • 2047-4830
  • 2047-4849
Abstract: 
Material surfaces that provide biomimetic cues, such as nanoscale architectures, have been shown to alter cell/biomaterial interactions. Recent studies have identified titania nanotube arrays as strong candidates for use in interfaces on implantable devices due to their ability to elicit improved cellular functionality. However, limited information exists regarding the immune response of nanotube arrays. Thus, in this study, we have investigated the short- and long-term immune cell reaction of titania nanotube arrays. Whole blood lysate (containing leukocytes, thrombocytes and trace amounts of erythrocytes), isolated from human blood, were cultured on titania nanotube arrays and biomedical grade titanium (as a control) for 2 hours and 2 and 7 days. In order to determine the in vitro immune response on titania nanotube arrays, immune cell functionality was evaluated by cellular viability, adhesion, proliferation, morphology, cytokine/chemokine expression, with and without lipopolysaccharide (LPS), and nitric oxide release. The results presented in this study indicate a decrease in short- and long-term monocyte, macrophage and neutrophil functionality on titania nanotube arrays as compared to the control substrate. This work shows a reduced stimulation of the immune response on titania nanotube arrays, identifying this specific nanoarchitecture as a potentially optimal interface for implantable biomedical devices. © 2013 The Royal Society of Chemistry.
Issue Date: 
1-Mar-2013
Citation: 
Biomaterials Science, v. 1, n. 3, p. 322-332, 2013.
Time Duration: 
322-332
Keywords: 
  • Cellular viability
  • Implantable biomedical devices
  • Implantable devices
  • Limited information
  • Lipopolysaccharides
  • Nanoscale architectures
  • Nitric oxide release
  • Titania nanotube arrays
  • Biomimetics
  • Blood
  • Immune system
  • Implants (surgical)
  • Nanotubes
  • Nitric oxide
  • Titanium dioxide
  • Cellular arrays
Source: 
http://dx.doi.org/10.1039/c2bm00079b
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/74698
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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