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Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress
  • Universidade de São Paulo (USP)
  • Fac Med ABC
  • Universidade Estadual Paulista (UNESP)
  • Departamento de Clinica Médica da Faculdade de Medicina de Ribeirao Preto da Universidade de São Paulo (USP)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Background: Exercise stress was shown to increase oxidative stress in rats. It lacks reports of increased protection afforded by dietary antioxidant supplements against ROS production during exercise stress. We evaluated the effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress.Methods: Wistar rats were divided into three groups: 1) control group; 2) exercise stress group and; 3) exercise stress + Vitamin E group. Rats from the group 3 were treated with gavage administration of 1 mL of Vitamin E (5 mg/kg) for seven consecutive days. Animals from groups 2 and 3 were submitted to a bout of swimming exhaustive exercise stress. Kidney samples were analyzed for Thiobarbituric Acid Reactive Substances to (TBARS) by malondialdehyde (MDA), reduced glutathione (GSH) and vitamin-E levels.Results: The group treated with vitamin E and submitted to exercise stress presented the lowest levels of renal MDA (1: 0.16+0.02 mmmol/mgprot vs. 2: 0.34+0.07 mmmol/mgprot vs. 3: 0.1+0.01 mmmol/mgprot; p < 0.0001), the highest levels of renal GSH (1: 23+4 mu mol/gprot vs. 2: 23+2 mu mol/gprot vs. 3: 58+9 mu mol/gprot; p < 0.0001) and the highest levels of renal vitamin E (1: 24+6 mu M/gtissue vs. 2: 28+2 mu M/gtissue vs. 3: 43+4 mu M/gtissue; p < 0.001).Conclusion: Vitamin E supplementation improved non-enzymatic antioxidant activity in young rats submitted to exhaustive exercise stress.
Issue Date: 
Bmc Complementary and Alternative Medicine. London: Biomed Central Ltd., v. 11, p. 6, 2011.
Time Duration: 
Biomed Central Ltd.
Access Rights: 
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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