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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/108310
Title: 
Inclusion complex of S(-) bupivacaine and 2-hydroxypropyl-β-cyclodextrin: study of morphology and cytotoxicity
Author(s): 
Institution: 
  • Universidade Estadual Paulista (UNESP)
  • Universidade Federal do Paraná (UFPR)
  • Universidade de São Paulo (USP)
  • Universidade Estadual de Campinas (UNICAMP)
  • Universidade de Sorocaba (UNISO)
ISSN: 
  • 1808-4532
  • 2179-443X
Abstract: 
Local anesthetics (LA) belong to a class of pharmacological compounds that attenuate or eliminate pain by binding to the sodium channel of excitable membranes, blocking the influx of sodium ions and the propagation of the nerve impulse. S (-) bupivacaine (S(-) bvc) is a local anesthetic of amino-amide type, widely used in surgery and obstetrics for sustained peripheral and central nerve blockade. This article focuses on the characterization of an inclusion complex of S(-) bvc in 2-hydroxypropyl-ß-cyclodextrin (HP-ß-CD). Differential scanning calorimetry, scanning electron microscopy and X-Ray diffraction analysis showed structural changes in the complex. In preliminary toxicity studies, the cell viability tests revealed that the inclusion complex decreased the toxic effect (p<0.001) produced by S(-) bvc. These results suggest that the S(-) bvc:HP-ß-CD inclusion complex represents a promising agent for the treatment of regional pain. Keywords: S(-) bupivacaine; cyclodextrin; inclusion complex.
Issue Date: 
2006
Citation: 
Revista de Ciências Farmacêuticas Básica e Aplicada, v. 27, n. 3, 2006, p. 207-212.
Publisher: 
Universidade Estadual Paulista (UNESP)
Keywords: 
  • S(-) bupivacaine
  • cyclodextrin
  • inclusion complex
  • Farmacotécnica
Source: 
http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/383
URI: 
Access Rights: 
Acesso aberto
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/108310
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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