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Platelet-Rich Plasma, Low-Level Laser Therapy, or Their Combination Promotes Periodontal Regeneration in Fenestration Defects: A Preliminary In Vivo Study
  • Universidade Estadual Paulista (UNESP)
  • Universidade de São Paulo (USP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Sponsorship Process Number: 
  • FAPESP: 08/53166-4
  • FAPESP: 08/52608-4
Background: This study histomorphometrically analyzes the influence of platelet- rich plasma (PRP), low- level laser therapy (LLLT), or their combination on the healing of periodontal fenestration defects (PFDs) in rats.Methods: PFDs were surgically created in the mandibles of 80 rats. The animals were randomly divided into four groups: 1) C (control) and 2) PRP, defects were filled with blood clot or PRP, respectively; 3) LLLT and 4) PRP/LLLT, defects received laser irradiation, were filled with blood clot or PRP, respectively, and then irradiated again. Animals were euthanized at either 10 or 30 days post-surgery. Percentage of new bone (NB), density of newly formed bone (DNB), new cementum (NC), and extension of remaining defect (ERD) were histomorphometrically evaluated. Data were statistically analyzed (analysis of variance; Tukey test, P < 0.05).Results: At 10 days, group PRP presented ERD significantly lower than group C. At 30 days, group PRP presented NB and DNB significantly greater than group C. Groups LLLT, PRP, and PRP/LLLT showed significant NC formation at 30 days, with collagen fibers inserted obliquely or perpendicularly to the root surface. NC formation was not observed in any group C specimen.Conclusions: LLLT, PRP, or their combination all promoted NC formation with a functional periodontal ligament. The combination PRP/LLLT did not show additional positive effects compared to the use of either therapy alone.
Issue Date: 
Journal Of Periodontology. Chicago: Amer Acad Periodontology, v. 85, n. 6, p. 770-778, 2014.
Time Duration: 
Amer Acad Periodontology
  • Laser therapy, low-level
  • models, animal
  • periodontics
  • platelet-rich plasma
  • regeneration
  • wounds and injuries
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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