Please use this identifier to cite or link to this item:
- Downmodulation of peripheral MUG-specific immunity by pVAXhspe65 treatment during EAE does not reach the CNS
- Universidade Estadual Paulista (UNESP)
- Fundacao Dr Amaral Carvalho
- Universidade de São Paulo (USP)
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- FAPESP: 11/07528-5
- Most of the therapeutic strategies to control multiple sclerosis are directed to immune modulation and inflammation control. As heat shock proteins are able to induce immunoregulatory T cells, we investigated the therapeutic effect of a genetic vaccine containing the mycobacterial hsp65 gene on experimental autoimmune encephalomyelitis (EAE). Although pVAXhsp65 was immunogenic for mice with EAE and downmodulated specific cytokine induction by MOG, therapy was not able to decrease clinical severity nor to modify immunologic parameters in the CNS. These results indicate that hsp65, administered as a DNA vaccine, was not therapeutic for EAE. (C) 2014 Elsevier B.V. All rights reserved.
- Journal Of Neuroimmunology. Amsterdam: Elsevier Science Bv, v. 268, n. 1-2, p. 35-42, 2014.
- Elsevier B.V.
- Experimental autoimmune encephalomyelitis hsp65
- DNA vaccine
- CD4+CD25+Foxp3+T cells
- Acesso restrito
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.