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- Immunomodulation in human and experimental arthritis: including vitamin D, helminths and heat-shock proteins
- Universidade Estadual Paulista (UNESP)
- Chaim Sheba Med Ctr
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- FAPESP: 11/17325-4
- Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is mainly directed to the joints, affecting the synovial membrane, the cartilage and also the bone. This disease affects 1% to 2% of the world population and is associated with significant morbidity and increased mortality. RA experimental models have allowed a great deal of information to be translated to the corresponding human disease. This review summarizes some of the most relevant findings targeting immunomodulation in arthritis. Some general guidelines to choose an adequate experimental model and also our experience with arthritis are supplied.
- Lupus. London: Sage Publications Ltd, v. 23, n. 6, p. 577-587, 2014.
- Sage Publications Ltd
- Rheumatoid arthritis
- vitamin D
- dendritic cells
- regulatory T cells
- heat-shock proteins
- Acesso restrito
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