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Seasonal genetic partitioning in the neotropical malaria vector, Anopheles darlingi
  • Universidade Estadual Paulista (UNESP)
  • Univ Nova Lisboa
  • IPEPATRO Inst Pesquisas Patologias Tropicais
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
  • Fundacao para a Ciencia e Tecnologia (FCT) /Ministerio da Educacao e Ciencia (MEC) through the European Social Fund (ESF)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Sponsorship Process Number: 
  • CAPES: capes128587311218103
  • Fundacao para a Ciencia e Tecnologia (FCT) /Ministerio da Educacao e Ciencia (MEC) through the European Social Fund (ESF)SFRH/BPD/72532/2010
Background: Anopheles darlingi is the main malaria mosquito vector in the Amazonia region. In spite of being considered a riverine, forest-dwelling species, this mosquito is becoming more abundant in peri-urban areas, increasing malaria risk. This has been associated with human-driven environmental changes such as deforestation.Methods: Microsatellites were used to characterize A. darlingi from seven localities along the Madeira River, Rondonia (Brazil), collected in the early and late periods of the rainy season.Results: Two genetically distinct subpopulations were detected: one (subpopulation A) was associated with the late rainfall period and seems to be ecologically closer to the typical forest A. darlingi; the other (subpopulation B) was associated with the early rainfall period and is probably more adapted to drier conditions by exploiting permanent anthropogenic breeding sites. Results suggest also a pattern of asymmetric introgression, with more subpopulation A alleles introgressed into subpopulation B. Both subpopulations (and admixed mosquitoes) presented similar malaria infection rates, highlighting the potential for perennial malaria transmission in the region.Conclusions: The co-occurrence of two genetically distinct subpopulations of A. darlingi adapted to different periods of rainfall may promote a more perennial transmission of malaria throughout the year. These findings, in a context of strong environmental impact due to deforestation and dam construction, have serious implications for malaria epidemiology and control in the Amazonian region.
Issue Date: 
Malaria Journal. London: Biomed Central Ltd, v. 13, 10 p., 2014.
Time Duration: 
Biomed Central Ltd.
  • Anopheles darlingi
  • Amazonia
  • Seasonal genetic structure
  • Microsatellites
  • Malaria
Access Rights: 
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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