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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/112720
Title: 
MALDI Imaging Analysis of Neuropeptides in the Africanized Honeybee (Apis mellifera) Brain: Effect of Ontogeny
Author(s): 
Institution: 
Universidade Estadual Paulista (UNESP)
ISSN: 
1535-3893
Sponsorship: 
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Sponsorship Process Number: 
FAPESP: 11/51684-1
Abstract: 
The occurrence and spatial distribution of the neuropeptides AmTRP-5 and AST-1 in the honeybee brain were monitored via MALDI spectral imaging according to the ontogeny of Africanized Apis mellifera. The levels of these peptides increased in the brains of 0-15 day old honeybees, and this increase was accompanied by an increase in the number of in-hive activities performed by the nurse bees, followed by a decrease in the period from 15 to 25 days of age, in which the workers began to perform activities outside the nest (guarding and foraging). The results obtained in the present investigation suggest that AmTRP-5 acts in the upper region of both pedunculi of young workers, possibly regulating the cell cleaning and brood capping activities. Meanwhile, the localized occurrence of AmTRP-5 and AST-1 in the antennal lobes, subesophageal ganglion, upper region of the medulla, both lobula, and alpha- and beta-lobes of both brain hemispheres in 20 to 25 day old workers suggest that the action of both neuropeptides in these regions may be related to their localized actions in these regions, regulating foraging and guarding activities. Thus, these neuropeptides appear to have some functions in the honeybee brain that are specifically related to the age-related division of labor.
Issue Date: 
1-Jun-2014
Citation: 
Journal Of Proteome Research. Washington: Amer Chemical Soc, v. 13, n. 6, p. 3054-3064, 2014.
Time Duration: 
3054-3064
Publisher: 
Amer Chemical Soc
Keywords: 
  • MALDI imaging
  • mass spectrometry
  • honeybee brain
  • neuropeptides
  • ontogeny
  • proteomics
Source: 
http://dx.doi.org/10.1021/pr500224b
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/112720
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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