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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/116204
Título: 
Biocompatible Microemulsion Modifies the Tissue Distribution of Doxorubicin
Autor(es): 
Instituição: 
Universidade Estadual Paulista (UNESP)
ISSN: 
0022-3549
Financiador: 
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento: 
FAPESP: 11/11239-9
Resumo: 
The incorporation of doxorubicin (DOX) in a microemulsion (DOX-ME) has shown beneficial consequences by reducing the cardiotoxic effects of DOX. The aim of this study was to determine the distribution of DOX-ME in Ehrlich solid tumor (EST) and the heart, and compare it with that of free DOX. The distribution study was conducted with female Swiss mice with EST (n = 7 per group; 20-25 g). Animals received a single dose (10 mg/kg, i.p.) of DOX or DOX-ME 7 days after tumor inoculation. Fifteen minutes after administration, the animals were sacrificed, and the tumor and heart tissues were taken for immediate analysis by ultra-performance liquid chromatography. No difference was observed in DOX concentration in tumor tissue between DOX and DOX-ME administration. However, the most remarkable result in this study was the statistically significant reduction in DOX concentration in heart tissue of animals given DOX-ME. Mean DOX concentration in heart tissue was 0.92 +/- 0.54 ng mg(-1) for DOX-ME and 1.85 +/- 0.34 ng mg(-1) for free DOX. In conclusion, DOX-ME provides a better tissue distribution profile, with a lower drug concentration in heart tissue but still comparable tumor drug concentration, which indicates that antitumor activity would not be compromised. (c) 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:3297-3301, 2014
Data de publicação: 
1-Out-2014
Citação: 
Journal Of Pharmaceutical Sciences. Hoboken: Wiley-blackwell, v. 103, n. 10, p. 3297-3301, 2014.
Duração: 
3297-3301
Publicador: 
Wiley-Blackwell
Palavras-chaves: 
  • microemulsion
  • formulation
  • doxorubicin
  • Ehrlich tumor
  • liquid chromatography
  • UPLC
  • distribution
  • pharmacokinetics
  • toxicology
Fonte: 
http://dx.doi.org/10.1002/jps.24106
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/116204
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