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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/11870
Título: 
Genetic, epidemiological and biological analysis of interleukin-10 promoter single-nucleotide polymorphisms suggests a definitive role for-819C/T in leprosy susceptibility
Autor(es): 
Instituição: 
  • Inst Lauro Souza Lima
  • Inst Oswaldo Cruz
  • Universidade Estadual Paulista (UNESP)
  • Fiocruz MS
ISSN: 
1466-4879
Resumo: 
Leprosy is a complex infectious disease influenced by genetic and environmental factors. The genetic contributing factors are considered heterogeneous and several genes have been consistently associated with susceptibility like PARK2, tumor necrosis factor (TNF), lymphotoxin-alpha (LTA) and vitamin-D receptor (VDR). Here, we combined a case-control study (374 patients and 380 controls), with meta-analysis (5 studies; 2702 individuals) and biological study to test the epidemiological and physiological relevance of the interleukin-10 (IL-10) genetic markers in leprosy. We observed that the -819T allele is associated with leprosy susceptibility either in the case-control or in the meta-analysis studies. Haplotypes combining promoter single-nucleotide polymorphisms also implicated a haplotype carrying the -819T allele in leprosy susceptibility (odds ratio (OR) = 1.40; P = 0.01). Finally, we tested IL-10 production in peripheral blood mononuclear cells stimulated with Mycobacterium leprae antigens and found that -819T carriers produced lower levels of IL-10 when compared with noncarriers. Taken together, these data suggest that low levels of IL-10 during the disease outcome can drive patients to a chronic and unprotective response that culminates with leprosy.
Data de publicação: 
1-Mar-2009
Citação: 
Genes and Immunity. London: Nature Publishing Group, v. 10, n. 2, p. 174-180, 2009.
Duração: 
174-180
Publicador: 
Nature Publishing Group
Palavras-chaves: 
  • leprosy
  • cytokines
  • interleukin-10
  • SNPs
  • tuberculosis
  • leishmaniasis
Fonte: 
http://dx.doi.org/10.1038/gene.2008.97
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/11870
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