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- Parecoxib reduces renal injury in an ischemia/reperfusion model in rats
- Universidade Estadual Paulista (UNESP)
- To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model. METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups. RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups. CONCLUSION: Parecoxib resulted in renal protection in this experimental model.
- Acta Cirurgica Brasileira, v. 30, n. 4, p. 270-276, 2015.
- Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
- Acesso aberto
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