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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/128528
Título: 
Effect of topical application of chlorhexidine and metronidazole on the tissue repair of palatal wounds of rats: a clinical and histomorphometric study
Autor(es): 
Instituição: 
  • Universidade Federal de Alfenas (UNIFAL)
  • Universidade Estadual Paulista (UNESP)
ISSN: 
2212-4403
Financiador: 
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
  • Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Resumo: 
Objective. This study investigated the effect of topical application of 2% chlorhexidine (GCl) and metronidazole (Gme) pastes for the repair of palatal wounds in rats.Study Design. A 4-mm diameter wound was created on the palates of 27 rats separated randomly into 3 groups of 9 animals each, according to the treatment received: GNa (Control: natrosol), GCl, and GMe. The animals were euthanized after 3, 6, and 10 days, and wound closure was clinically and histomorphometrically assessed.Results. Clinical evaluation showed a statistically significant difference in tissue repair with GCl and GMe compared with GNa. In histomorphometric analysis, the highest values in the areas of the epithelium and keratin were observed for GCl and GMe; however, compared with Gna, no statistically significant differences were observed.Conclusions. GCl and GMe pastes showed promising results with regard to tissue repair from a clinical point of view. Histologically, premature closure of wounds was noted in most specimens on day 6. Although no statistically significant differences were observed among the experimental groups with regard to histometry of the epithelium and keratin, the highest means were observed for GCl.
Data de publicação: 
1-Mai-2015
Citação: 
Oral Surgery Oral Medicine Oral Pathology Oral Radiology, v. 119, n. 5, p. 505-513, 2015.
Duração: 
505-513
Publicador: 
Elsevier B.V.
Fonte: 
http://www.sciencedirect.com/science/article/pii/S2212440314014527
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/128528
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