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- Pyridinic analog of the natural product (-)-spectaline as potential adjuvant for the treatment of central nervous system disorders
- Universidade Estadual Paulista (UNESP)
- Universidade Federal do Rio Grande do Sul (UFRGS)
- Universidade Federal do Triângulo Mineiro (UFTM)
- Universidade Federal de Uberlândia (UFU)
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
- FAPESP: 03/02176-7
- FAPESP: 2013/07600-3
- FAPESP: 2010/52327-5
- CNPq: 573.564/2008-6
- Previously we designed a series of pyridinic anticholinesterasic compounds based on molecular hybridization between tacrine and the natural piperidine alkaloid (-)-3-O-acetylspectaline isolated from Senna spectabilis. Based on the information that the cholinergic system has an important role in the treatment of schizophrenia and depression, we herein report the evaluation of a series of pyridinic compounds in animal models for antipsychotic and antidepressant-like activities. Compound 2 decreased the immobility time of mice in the forced swimming test (5 and 10 mg/kg p.o.) and prevented the climbing behavior induced by apomorphine (10 mg/kg, p.o.), without impairing animals locomotor activity.
- Bioorganic & Medicinal Chemistry Letters. Oxford: Pergamon-elsevier Science Ltd, v. 25, n. 10, p. 2247-2250, 2015.
- Elsevier B.V.
- Pyridinic alkaloid analogs
- Antidepressant-like activity
- Apomorphine-induced climbing
- Forced swimming test
- Acesso restrito
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