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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/129401
Título: 
Effect of low-level laser therapy (LLLT) on peripheral nerve regeneration using fibrin glue derived from snake venom
Autor(es): 
Instituição: 
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
  • Universidade Estadual de Campinas (UNICAMP)
ISSN: 
0020-1383
Financiador: 
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento: 
FAPESP: 2010/16.883-0
Resumo: 
Objectives: The purpose of this study was to assess whether the adhesive permits the collateral repair of axons originating from a vagus nerve to the interior of a sural nerve graft, and whether low-level laser therapy (LLLT) assists in the regeneration process.Materials and methods: Study sample consisted of 32 rats randomly separated into three groups: Control Group (CG; n = 8), from which the intact sural nerve was collected; Experimental Group (EG; n = 12), in which one of the ends of the sural nerve graft was coapted to the vagus nerve using the fibrin glue; and Experimental Group Laser (EGL; n = 12), in which the animals underwent the same procedures as those in EG with the addition of LLLT. Ten weeks after surgery, the animals were euthanized. Morphological analysis by means of optical and electron microscopy, and morphometry of the regenerated fibers were employed to evaluate the results.Results: Collateral regeneration of axons was observed from the vagus nerve to the interior of the autologous graft in EG and EGL, and in CG all dimensions measured were greater and presented a significant difference in relation to EG and EGL, except for the area and thickness of the myelin sheath, that showed significant difference only in relation to the EG.Conclusions: The present study demonstrated that the fibrin glue makes axonal regeneration feasible and is an efficient method to recover injured peripheral nerves, and the use of low-level laser therapy enhances nerve regeneration. (C) 2015 Elsevier Ltd. All rights reserved.
Data de publicação: 
1-Abr-2015
Citação: 
Injury-international Journal Of The Care Of The Injured, v. 46, n. 4, p. 655-660, 2015.
Duração: 
655-660
Publicador: 
Elsevier B.V.
Palavras-chaves: 
  • Fibrin glue
  • Low-level laser therapy
  • Nerve regeneration
  • Peripheral nerve injury
  • Sural nerve
  • Vagus nerve
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/129401
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