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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/129688
Title: 
Genome-wide association with residual body weight gain in Bos indicus cattle
Author(s): 
Institution: 
  • Faculdade de Zootecnia e Engenharia de Alimentos
  • Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
  • Universidade Estadual Paulista (UNESP)
  • GenSys Consultores Associados SC Ltda
  • Universidade de São Paulo (USP)
ISSN: 
1676-5680
Sponsorship: 
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Sponsorship Process Number: 
  • FAPESP: 2012/02039-9
  • FAPESP: 2013/20571-2
Abstract: 
Weight gain is a key performance trait for beef cattle; however, attention should be given to the production costs for better profitability. Therefore, a feed efficiency trait based on performance can be an interesting approach to improve performance without increasing food costs. To identify candidate genes and genomic regions associated with residual body weight gain (RWG), we conducted a genome-wide association study (GWAS) with 720 Nellore cattle using the GRAMMAR-Gamma association test. We identified 30 significant single nucleotide polymorphisms (SNPs), especially on chromosomes 2, 8, 12, and 17. Several genes and quantitative train loci (QTLs) present in the regions identified were appointed; we highlight DMRT2 (doublesex and mab-3 related transcription factor 2), IFFO2 (intermediate filament family orphan 2), LNX2 (ligand of numb-protein X 2), MTIF3 (mitochondrial translational initiation factor 3), and TRNAG-CCC (transfer RNA glycine anticodon CCC). The metabolic pathways that can explain part of the phenotypic variation in RWG are related to oxidative stress and muscle control.
Issue Date: 
1-Jan-2015
Citation: 
Genetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 14, n. 2, p. 5229-5233, 2015.
Time Duration: 
5229-5233
Publisher: 
Funpec-editora
Keywords: 
  • Beef cattle
  • Nellore
  • Feed efficiency
  • Average daily gain
  • Genome-wide association study
  • Single nucleotide polymorphism
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/129688
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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