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Morphology of ileal and jejunal pouches used as rectal substitutes
  • Mayo Clin Scottsdale
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
PURPOSE: Our aim was to determine whether the mucosa of a canine jejunal pouch used as a rectal substitute after proctocolectomy retains its morphologic features better than the mucosa of a canine ileal pouch so used. METHODS: Among ten dogs that underwent proctocolectomy, five had a jejunal pouch-distal rectal anastomosis and five an ileal pouch-distal rectal anastomosis. After six months, the animals were killed, the intestinal pouches and portions of unaltered distal ileum were removed, and a blinded, mucosal morphometric analysis was performed. RESULTS: The mucosa of the jejunal pouches had an overall thickness (mean ± standard deviation, anterior and posterior walls, 1,300 ± 140 μm), villous height (286 ± 46 μm), and crypt depth (790 ± 77 μm) greater than that of the ileal pouches (920 ± 170, 208 ± 47, and 530 ± 130 μm, respectively; P < 0.05). Moreover, the mucosal thickness of the jejunal pouches was similar to that of the distal ileum proximal to the pouch (1,200 ± 200 μm; P > 0.05), whereas the mucosal thickness of the ileal pouch was thinner (P < 0.05). CONCLUSIONS: The jejunal mucosa retains its major morphometric features when the jejunum is used as a rectal substitute after proctocolectomy. In contrast, the ileal mucosa atrophies when the ileum is so used.
Issue Date: 
Diseases of the Colon and Rectum, v. 46, n. 3, p. 373-376, 2003.
Time Duration: 
Lippincott Williams & Wilkins
  • Ileal pouch-anal canal anastomosis
  • Jejunal pouch-anal canal anastomosis
  • Proctocolectomy
  • Animal cell
  • Animal experiment
  • Animal tissue
  • Controlled study
  • Dog
  • Female
  • Ileoanal anastomosis
  • Ileum pouch
  • Intestine crypt
  • Intestine metaplasia
  • Intestine mucosa
  • Intestine villus
  • Jejunum
  • Jejunum pouch
  • Morphometrics
  • Nonhuman
  • Proctocolectomy
  • Prosthesis
  • Rectum prosthesis
  • Animals
  • Colonic Pouches
  • Dogs
  • Female
  • Intestinal Mucosa
  • Models, Animal
  • Proctocolectomy, Restorative
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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