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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/13122
Título: 
Is urine interleukin-8 level a reliable laboratory test for diagnosing late onset sepsis in premature infants?
Autor(es): 
Instituição: 
Universidade Estadual Paulista (UNESP)
ISSN: 
0142-6338
Resumo: 
The present study is aimed to determine serum and urine interleukin-8 (IL-8) levels in premature infants with late onset sepsis (LOS) and to evaluate if urine IL-8 is a useful test for LOS diagnosis. Fifty-six premature infants admitted to the NICU over 1 year had serum and urine IL-8 determined by ELISA. They were divided into three groups: I definite sepsis, II probable sepsis and III non-infected. Results were expressed as mean or median. Differences between groups were assessed by ANOVA, Kruskal-Wallis ANOVA and Dunns Method. Sensitivity, specificity and positive and negative predictive values were calculated and a receiver operator characteristic curve was constructed to determine serum and urine IL-8 accuracy. There were no differences between groups for birth weight, and gestational and post-natal age. Median serum and urine IL-8 levels were significantly higher in GI and GII: 929 x 906 x 625pg/ml; P=0.024, and 249 x 189 x 42pg/mgCr; P< 0.001. Optimal cut-off point was 625pg/ml for serum IL-8 with 69 sensitivity and 75pg/mgCr for urine IL-8 with 92 sensitivity. IL-8 can be determined in urine from premature infants with LOS and is an accurate and feasible diagnosis method.
Data de publicação: 
1-Dez-2007
Citação: 
Journal of Tropical Pediatrics. Oxford: Oxford Univ Press, v. 53, n. 6, p. 403-408, 2007.
Duração: 
403-408
Publicador: 
Oxford University Press
Fonte: 
http://dx.doi.org/10.1093/tropej/fmm054
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/13122
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