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Factors associated with red blood cell transfusions in very-low-birth-weight preterm infants in Brazilian neonatal units
  • Universidade Federal de São Paulo (UNIFESP)
  • Universidade Federal do Rio Grande do Sul (UFRGS)
  • Universidade Estadual de Campinas (UNICAMP)
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
  • Fundação Oswaldo Cruz
  • Pontifícia Universidade Católica do Rio Grande do Sul (PUC-RS)
  • Universidade Estadual de Londrina (UEL)
  • Instituto de Medicina Integral Professor Fernando Figueira
  • Universidade Federal do Paraná (UFPR)
  • Universidade Federal de Uberlândia (UFU)
  • Universidade do Estado de Rio de Janeiro (UERJ)
  • Universidade Federal do Maranhão (UFMA)
  • Universidade Federal de Minas Gerais (UFMG)
  • Faculdade de Ciências Médicas de Minas (FCMMG)
Ministry of Health of Brazil
Sponsorship Process Number: 
Ministry of Health of Brazil: 1755/2000
Preterm infants in neonatal intensive care units frequently receive red blood cells (RBC) transfusions due to the anemia of prematurity. A number of variables related to gestational age, severity of illness and transfusion practices adopted in the neonatal unit where the neonate was born may contribute to the prescription of RBC transfusions. This study aimed to analyse the frequency and factors associated with RBC transfusions in very-low-birth-weight preterm infants. A prospective cohort of 4283 preterm infants (gestational age: 29.9 ± 2.9 weeks; birth weight: 1084 ± 275 g) carried out at 16 university hospitals in Brazil between January 2009 and December 2011 was analysed. Factors associated with RBC transfusions were evaluated using univariate and multiple logistic regression analysis. A total of 2208 (51.6%) infants received RBC transfusions (variation per neonatal unit: 34.1% to 66.4%). RBC transfusions were significantly associated with gestational age (OR: -1.098; 95%CI: -1.12 to -1.04), SNAPPE II score (1.01; 1.00-1.02), apnea (1.69; 1.34-2.14), pulmonary hemorrhage (2.65; 1.74-4.031), need for oxygen at 28 days of life (1.56; 1.17-2.08), clinical sepsis (3.22; 2.55-4.05), necrotising enterocolitis (3.80; 2.26-6.41), grades III/IV intraventricular hemorrhage (1.64; 1.05-2.58), mechanical ventilation (2.27; 1.74-2.97), use of umbilical catheter (1.86; 1.35-2.57), parenteral nutrition (2.06; 1.27-3.33), >60 days of hospitalization (5.29; 4.02-6.95) and the neonatal unit where the neonate was born. The frequency of RBC transfusions varied among neonatal intensive care units. Even after adjusting for adverse health conditions and therapeutic interventions, the neonatal unit continued to influence transfusion practices in very-low birth-weight infants.
Issue Date: 
BMC Pediatrics, v. 15, p. 113-120, 2015.
Time Duration: 
BioMed Central LTD
  • Very low birth weight infants
  • Neonatal intensive care unit
  • Anemia
  • Red blood cell transfusion
  • Risk factors
Access Rights: 
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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