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- A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis
- Universidade Estadual Paulista (UNESP)
- Department of Biotechnology, Institute for Technical Microbiology, Hochschule Mannheim, 68163 Mannheim, Germany;
- Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule (ETH) Zürich, 8093 Zürich, Switzerland;
- Department of Biology, Technical University Darmstadt, 64287 Darmstadt, Germany.
- Department of Biotechnology, Institute for Technical Microbiology, Hochschule Mannheim, 68163 Mannheim, Germany; firstname.lastname@example.org.
- Flavin mononucleotide (FMN) riboswitches are genetic elements, which in many bacteria control genes responsible for biosynthesis and/or transport of riboflavin (rib genes). Cytoplasmic riboflavin is rapidly and almost completely converted to FMN by flavokinases. When cytoplasmic levels of FMN are sufficient (high levels), FMN binding to FMN riboswitches leads to a reduction of rib gene expression. We report here that the protein RibR counteracts the FMN-induced turn-off activities of both FMN riboswitches in Bacillus subtilis, allowing rib gene expression even in the presence of high levels of FMN. The reason for this secondary metabolic control by RibR is to couple sulfur metabolism with riboflavin metabolism.
- Proceedings Of The National Academy Of Sciences Of The United States Of America, p. 14054–14059, 2015.
- Bacillus subtilis
- Fmn riboswitch
- Flavin mononucleotide
- Acesso restrito
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