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Mapping brain Fos immunoreactivity in response to water deprivation and partial rehydration: influence of sodium intake
  • Universidad Nacional de Córdoba
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
  • Secretaría de Ciencia y Tecnología (SECyT)
  • Ministerio de Ciencia, Tecnología e Innovación Productiva (Mincyt)
  • Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT)
Sponsorship Process Number: 
  • CNPq: 301296/2009-0
  • FAPESP-PRONEX: 2011/50770-1
  • CONICET: PIP 2013-2015
  • SECyT: PID 2014-2015
  • Mincyt: PID 116-2010
  • ANPCyT: PICT 2010-2072
Water deprivation (WD) followed by water intake to satiety, produces satiation of thirst and partial rehydration (PR). Thus, WD-PR is a natural method to differentiate thirst from sodium appetite. WD-PR also produces Fos immunoreactivity (Fos-ir) in interconnected areas of a brain circuit postulated to subserve sodium appetite. In the present work, we evaluated the effect of sodium intake on Fos-ir produced by WD-PR in brain areas operationally defined according to the literature as either facilitatory or inhibitory to sodium intake. Isotonic NaCl was available for ingestion in a sodium appetite test performed immediately after a single episode of WD-PR. Sodium intake decreased Fos-ir in facilitatory areas such as the lamina terminalis (particularly subfornical organ and median preoptic nucleus), central amygdala and hypothalamic parvocellular paraventricular nucleus in the forebrain. Sodium intake also decreased Fos-ir in inhibitory areas such as the area postrema, lateral parabrachial nucleus and nucleus of the solitary tract in the hindbrain. In contrast, sodium intake further increased Fos-ir that was activated by water deprivation in the dorsal raphe nucleus, another inhibitory area localized in the hindbrain. WD-PR increased Fos-ir in the core and shell of the nucleus accumbens. Sodium intake reduced Fos-ir in both parts of the accumbens. In summary, sodium intake following WD-PR reduced Fos-ir in most facilitatory and inhibitory areas, but increased Fos-ir in another inhibitory area. It also reduced Fos-ir in a reward area (accumbens). The results suggest a functional link between sodium intake and the activity of the hindbrain-forebrain circuitry subserving reward and sodium appetite in response to water deprivation.
Issue Date: 
Physiology & Behavior, v. 151, p. 494-501, 2015.
Time Duration: 
Elsevier B. V.
  • Angiotensin ii
  • Reward
  • Satiety
  • Sodium appetite
  • Thirst
  • Water intake
Access Rights: 
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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