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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/133703
Title: 
Effect of byrosima crassa and phenolic constituents on helicobacter pylori: induced neutrophils oxdative burst
Author(s): 
Institution: 
  • Universidade Estadual Paulista (UNESP)
  • Universidade de São Paulo (USP)
ISSN: 
1422-0067
Sponsorship: 
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Abstract: 
Byrsonima crassa Niedenzu (Malpighiaceae) is used in Brazilian folk medicine for the treatment of diseases related mainly to gastric ulcers. In a previous study, our group described the gastric protective effect of the methanolic extract from the leaves of B. crassa. The present study was carried out to investigate the effects of methanolic extract and its phenolic compounds on the respiratory burst of neutrophils stimulated by H. pylori using a luminol-based chemiluminescence assay as well as their anti-H. pylori activity. The suppressive activity on oxidative burst of H. pylori-stimulated neutrophils was in the order of methyl gallate > (+)-catechin > methanol extract > quercetin 3-O-α-l-arabinopyranoside > quercetin 3-O-β-d-galactopyranoside > amentoflavone. Methyl gallate, compound that induced the highest suppressive activity with IC50 value of 3.4 μg/mL, did not show anti-H. pylori activity. B. crassa could be considered as a potential source of natural antioxidant in gastric ulcers by attenuating the effects on the damage to gastric mucosa caused by neutrophil generated reactive oxygen species, even when H. pylori displays its evasion mechanisms.
Issue Date: 
2012
Citation: 
International Journal of Molecular Sciences, v. 13, n. 1, p. 133-141, 2012.
Time Duration: 
133-141
Keywords: 
  • Byrsonima crassa
  • Helicobacter pylori
  • Gastric ulcers
  • Antioxidant activity
  • Phenolic compounds
  • Chemiluminescence
Source: 
http://dx.doi.org/10.3390/ijms13010133
URI: 
Access Rights: 
Acesso aberto
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/133703
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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