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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/137234
Title: 
Synergism of crude extracts and essential oils from medicinal plants with antimicrobial drugs
Author(s): 
Institution: 
Universidade Estadual Paulista (UNESP)
ISSN: 
2236-4308
Abstract: 
The emergence of resistant strains to conventional antimicrobial drugs has been constant as well as research aimed new alternatives of antibacterial agents. Therefore, considering that natural products have been an important potential source of new antimicrobial drugs, aim to verify the synergism by disk and time kill curve method between antimicrobials (extracts-Ext. and essential oils-EO) from four plant and eight antimicrobial drugs against Staphylococcus aureus and Escherichia coli strains from human specimens. The S. aures strains were highly susceptible with all plant antimicrobials (eg., 1.24 mg/ml with Vernonia polyanthes Ext. and 2.21 mg/ml with Eugenia uniflora EO for the Minimal Inhibitory Concentration-MIC). According disk method, the Bacharis dracunculifolia and V. polyanthes EO had synergism with all eight tested drugs while only Matricaria chamomilla Ext. showed synergism against S. aureus. The synergism was found with V. polyanthes and E. uniflora Ext. while M. chamomilla Ext. had antagonism against E. coli strains. By time kill curve, the bacterial growth inhibition was superior when drugs were tested alone and the synergism effect also was verified. The antagonism effect was detected only for E. coli strains and only with Ext. Results indicated the potential use of these products as coadjutants during treatment of infectious diseases.
Issue Date: 
2013
Citation: 
Journal of Antimicrobials, v. 128, n. 1, p. 189-197, 2013.
Time Duration: 
189-197
Keywords: 
  • Antimicrobial activity
  • Essential oils
  • Methanolic extract
  • Medicinal plants
  • S. aureus
  • E. coli
  • P. Aeruginosa
Source: 
https://sites.google.com/site/photonjournals/home/journal-of-antimicrobials
URI: 
Access Rights: 
Acesso aberto
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/137234
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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