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Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina
Chiku, Vanessa Marim
Universidade Estadual Paulista (UNESP)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Sponsorship Process Number: 
FAPESP: 2013/066849
Dogs infected with Leishmania infantum showed a reduction in the number of lymphocytes T. PD-1 (Programmed cell death 1) a new member of the B7-CD28 family, it is expressed by cells of the immune system and its binding to PD-L1 (CD274) or PD-L2 (CD273) induces deactivation of T cells or apoptosis. This study aimed to evaluate the PD-1 expression and its ligands as well as their role in T lymphocyte induction of apoptosis, TNF-α and IL-4 secretion, nitric oxide production and parasite load in dogs with visceral leishmaniasis. We observed that in canine visceral leishmaniasis PD-1 and its ligands involved in induction of apoptosis of T lymphocytes, are regulating the nitric oxide production, TNF-α, IL-4, as well as the parasitic load. This study helps to clarify the mechanism of immune response and immunotherapeutic drugs such as blocking monoclonal antibodies that can influence the LVC
Issue Date: 
CHIKU, Vanessa Marim. Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina. 2015. 67 f. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária, 2015.
Time Duration: 
67 f.
Universidade Estadual Paulista (UNESP)
  • Cães
  • Leishmaniose visceral
  • Leishmaniose
  • Anticorpos monoclonais
  • Celulas T
  • Leishmania infantum
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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