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Lethal photosensitization and guided bone regeneration in treatment of peri-implantitis: an experimental study in dogs
  • Universidade Estadual Paulista (UNESP)
  • Guarulhos Univ
  • Universidade de Marília (UNIMAR)
  • Universidade Estadual de Campinas (UNICAMP)
The purpose of this study was to evaluate the effect of lethal photosensitization and guided bone regeneration (GBR) on the treatment of ligature-induced peri-implantitis in different implant surfaces. The treatment outcome was evaluated by clinical and histometric methods. A total of 40 dental implants with four different surface coatings (10 commercially pure titanium surface (cpTi); 10 titanium plasma-sprayed (TPS); 10 acid-etched surface; 10 surface-oxide sandblasted) were inserted into five mongrel dogs. After 3 months, the animals with ligature-induced peri-implantitis were subjected to surgical treatment using a split-mouth design. The controls were treated by debridment and GBR, while the test side received an additional therapy with photosensitization, using a GaAlAs diode laser, with a wavelength of 830 nm and a power output of 50 mW for 80 s (4 J/cm(2)), and sensitized toluidine blue O (100 mu g/ml). The animals were sacrificed 5 months after therapy. The control sites presented an earlier exposition of the membranes on all coating surfaces, while the test group presented a higher bone height gain. Re-osseointegration ranged between 41.9% for the cpTi surface and 31.19% for the TPS surface in the test sites; however differences were not achieved between the surfaces. The lethal photosensitization associated with GBR allowed for better re-osseointegration at the area adjacent to the peri-implant defect regardless of the implant surface.
Issue Date: 
Clinical Oral Implants Research. Oxford: Blackwell Publishing, v. 17, n. 3, p. 273-281, 2006.
Time Duration: 
Blackwell Publishing
  • guided bone regeneration
  • histology
  • peri-implantitis
  • photodynamic therapy
  • photosensitizers
  • re-osseointegration
Access Rights: 
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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