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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/15877
Título: 
Influence of cyclosporin A on quality of bone around integrated dental implants: a radiographic study in rabbits
Autor(es): 
Instituição: 
  • Universidade Estadual Paulista (UNESP)
  • Univ Aarhus
ISSN: 
0905-7161
Resumo: 
To evaluate the influence of cyclosporin A (CsA) administration on bone around integrated dental implants assessed by a bone quality index and by quantitative subtraction radiography.A total of 36 machine surface commercial implants were placed in 18 adult rabbits. After a 3-month healing period without any disturbance, the animals were randomly divided into three groups of six animals each. Group A was sacrificed at this time. CsA was injected subcutaneously in an immunosuppressive dose of 10 mg/kg/day in a test group (Group T), and a Group B served as a control, receiving only vehicle. After 3 months of cyclosporin administration, the animals of both Groups B and T were sacrificed. Radiographs were obtained at implant surgery and at the day of sacrifice with a CMOS sensor. Bone quality around the implants was compared between the groups using a bone quality index and quantitative subtraction radiography.The bone analysis showed that in Group T, the bone quality changed dramatically from a dense cortical to a loose trabecular bone structure (P < 0.0001, chi(2) test) while in Groups A and B there were no significant differences. Quantitative digital subtraction radiography showed significantly (P < 0.05) lower gray shade values (radiographic density) in a region of bone formation around the implants in Group T (118 +/- 12) than in Groups A (161 +/- 6) and B (186 +/- 10).Within the limits of this study, CsA administration has a negative effect on the quality of bone around integrated dental implant.
Data de publicação: 
1-Fev-2007
Citação: 
Clinical Oral Implants Research. Oxford: Blackwell Publishing, v. 18, n. 1, p. 34-39, 2007.
Duração: 
34-39
Publicador: 
Blackwell Publishing
Palavras-chaves: 
  • bone density
  • cyclosporin
  • subtraction radiograph
  • titanium implants
Fonte: 
http://dx.doi.org/10.1111/j.1600-0501.2006.01253.x
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/15877
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