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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/15942
Title: 
Evaluation of chitosan gel as antibiotic and photosensitizer delivery
Author(s): 
Institution: 
  • Universidade Estadual Paulista (UNESP)
  • University of Windsor
ISSN: 
1071-7544
Sponsorship: 
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Abstract: 
This work suggests the use of chitosan gel imbued with the photosensitizer Photogem and with the antibiotic Tetraclin as a possible drug delivery system. The results reveal a decrease in the photosensitizer level of toxicity. Besides, the interaction between Photogem and chitosan gel causes a red shift in the photosensitizer spectrum, increasing its absorption in the therapeutic window (600-700 nm). These characteristics indicate this compound as a promising natural polymer-based photosensitizer carrier for photodynamic therapy. In summary, our results show that pure and doped chitosan gel may have potential application for antimicrobial action, being an excellent alternative when local control of the drug administration, provided by the gel, is required.
Issue Date: 
1-Jan-2008
Citation: 
Drug Delivery. London: Informa Healthcare, v. 15, n. 7, p. 417-422, 2008.
Time Duration: 
417-422
Publisher: 
Informa Healthcare
Keywords: 
  • antimicrobial
  • chitosan
  • chitin
  • drug release
  • less toxicity
  • photosensitizer
  • spectroscopy
Source: 
http://dx.doi.org/10.1080/10717540802007433
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/15942
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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