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- MAP Kinase Phosphatase-1 Protects against Inflammatory Bone Loss
- Med Univ S Carolina
- Universidade Estadual Paulista (UNESP)
- University of Michigan
- National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
- National Center for Research Resources
- NIDCR, NIH, Bethesda, MD 20892, USA: 1R01DE018290
- NCRR: 3P20 RR017696
- The mitogen-activated protein (MAP) kinase phosphatase (MKP) family plays an important function in regulating the pro-inflammatory cytokines by deactivating MAP kinases. MKP-1 is essential for the dephosphorylation of p38 MAP kinase that regulates expression of IL-6, TNF-alpha, and IL-1 beta. We hypothesized that MKP-1 regulates inflammatory bone loss in experimental periodontitis. Wild-type and Mkp-1(-/-) mice received A. actinomycetemcomitans LPS injection in the palatal region or PBS control 3 times/wk for 30 days. Mice were killed, and maxillae were assessed by microcomputed tomography, histological analysis, and TRAP staining for measurement of bone loss, extent of inflammation, and degree of osteoclastogenesis. Results indicated that, in LPS-injected Mkp-1(-/-) mice, significantly greater bone loss occurred with more inflammatory infiltrate and a significant increase in osteoclastogenesis compared with Mkp-1(-/-) control sites or either wild-type group. Analysis of these data indicates that MKP-1 plays a key role in the regulation of inflammatory bone loss.
- Journal of Dental Research. Thousand Oaks: Sage Publications Inc, v. 88, n. 12, p. 1125-1130, 2009.
- Sage Publications Inc
- innate immunity
- periodontal disease
- Acesso restrito
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