Please use this identifier to cite or link to this item:
- Implication of RNA-Binding Protein La in Proliferation, Migration and Invasion of Lymph Node-Metastasized Hypopharyngeal SCC Cells
- Med Univ S Carolina
- Universidade Estadual Paulista (UNESP)
- Department of Biochemistry & Molecular Biology (MUSC)
- SC COBRE for Oral Health Research
- Cancer Center
- SC COHR: P20RR017696-09
- NIH/NCRR: 1R03DE021729-01
- Cancer Center: P30 CA138313
- The 5-year survival rate for oral cavity cancer is poorer than for breast, colon or prostate cancer, and has improved only slightly in the last three decades. Hence, new therapeutic strategies are urgently needed. Here we demonstrate by tissue micro array analysis for the first time that RNA-binding protein La is significantly overexpressed in oral squamous cell carcinoma (SCC). Within this study we therefore addressed the question whether siRNA-mediated depletion of the La protein may interfere with known tumor-promoting characteristics of head and neck SCC cells. Our studies demonstrate that the La protein promotes cell proliferation, migration and invasion of lymph node-metastasized hypopharyngeal SCC cells. We also reveal that La is required for the expression of beta-catenin as well as matrix metalloproteinase type 2 (MMP-2) within these cells. Taken together these data suggest a so far unknown function of the RNA-binding protein La in promoting tumor progression of head and neck SCC.
- Plos One. San Francisco: Public Library Science, v. 6, n. 10, p. 8, 2011.
- Public Library Science
- Acesso aberto
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.