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Role of serotonergic 5-HT1A and oxytocinergic receptors of the lateral septal area in sodium intake regulation
  • Universidade Estadual Paulista (UNESP)
  • Universidade Federal de São Carlos (UFSCar)
  • Univ Taubate
  • Univ Araraquara
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • Brazilian research funding agencies
Several reports have revealed a high density of 5-HT1A receptors in the lateral septal area (LSA), as well as a subpopulation of oxytocin (OT) receptors. Increasing evidence shows that 5-HT1A and OT neurons inhibit sodium urinary excretion. The aim of this study was to investigate the part played by serotonergic(5-HT1A) and oxytocinergic receptors in the LSA in the sodium intake induced in rats by sodium depletion followed by 24 h deprivation. Cannulae were implanted bilaterally into the LSA of rats to enable the introduction of receptor ligands into that brain area. Serotonergic injections of 5-HT (10, 20, and 40 mu g/0.2 mu L) reduced 1.8% NaCl solution intake, but injections (1, 2, and 4 mu g/0.2 mu L) of 8-OH-DPAT, a 5-HT1A agonist, were more effective than 5-HT in reducing 1.8% NaCl intake. Pretreatment of the LSA with the 5-HT1A antagonist pMPPF partially reduced the inhibitory effect of 5-HT and totally reversed the effects of 8-OH-DPAT on 1.8% NaCl intake induced by sodium depletion. Previous treatment with the potent oxytocin receptor antagonist d(CH2)(5)[Tyr(Me)(2)Thr(4), Orn(5), Tyr(NH2)(9)]-vasotocin also totally blocked the inhibitory effects of 5-HT or 8-OH-DPAT on 1.8% NaCl intake. These results show that 5-HTIA serotonergic receptors in the LSA, including some that interact with the oxytocinergic system, modulate sodium intake induced by sodium loss in rats. (C) 2010 Elsevier B.V. All rights reserved.
Issue Date: 
Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 209, n. 2, p. 260-266, 2010.
Time Duration: 
Elsevier B.V.
  • Lateral septum
  • Sodium intake
  • 5-HT1A
  • 8-OH-DPAT
  • pMPPF
  • Oxytocin antagonist
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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