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- Local and cardiorenal effects of periodontitis in nitric oxide-deficient hypertensive rats
- Universidade de São Paulo (USP)
- Boston University
- Universidade Estadual Paulista (UNESP)
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- National Institute of Dental and Craniofacial Research, National Institutes of Health
- FAPESP: 02/00300-0
- CNPq: 475549/2004-0
- NIDCR, NIH: DE16933
- NIDCR, NIH: DE15566
- Objective: In this study we have assessed the renal and cardiac consequences of ligature-induced periodontitis in both normotensive and nitric oxide (NO)-deficient (L-NAME-treated) hypertensive rats.Materials and methods: Oral L-NAME (or water) treatment was started two weeks prior to induction of periodontitis. Rats were sacrificed 3, 7 or 14 days after ligature placement, and alveolar bone loss was evaluated radiographically. Thiobarbituric reactive species (TBARS; a lipid peroxidation index), protein nitrotyrosine (NT; a marker of protein nitration) and myeloperoxidase activity (MPO; a neutrophil marker) were determined in the heart and kidney.Results: In NO-deficient hypertensive rats, periodontitis-induced alveolar bone loss was significantly diminished. In addition, periodontitis-induced cardiac NT elevation was completely prevented by L-NAME treatment. on the other hand L-NAME treatment enhanced MPO production in both heart and kidneys of rats with periodontitis. No changes due to periodontitis were observed in cardiac or renal TBARS content.Conclusions: In addition to mediating alveolar bone loss, NO contributes to systemic effects of periodontitis in the heart and kidney. (C) 2010 Elsevier Ltd. All rights reserved.
- Archives of Oral Biology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 56, n. 1, p. 41-47, 2011.
- Pergamon-Elsevier B.V. Ltd
- Nitric oxide
- Lipid peroxidation
- Acesso restrito
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