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Effect of an acrylic resin combined with an antimicrobial polymer on biofilm formation
  • Univ Paulista
  • Universidade Estadual Paulista (UNESP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Sponsorship Process Number: 
  • FAPESP: 08/02602-0
  • FAPESP: 07/04061-3
Objectives: The purpose of this study was to evaluate the antimicrobial activity of an acrylic resin combined with an antimicrobial polymer poly (2-tert-butylaminoethyl) methacrylate (PTBAEMA) to inhibit Staphylococcus aureus, Streptococcus mutans and Candida albicans biofilm formation. Material and Methods: Discs of a heat-polymerized acrylic resin were produced and divided according to PTBAEMA concentration: 0 (control), 10 and 25%. The specimens were inoculated (10(7) CFU/mL) and incubated at 37 degrees C for 48 h. After incubation, the wells were washed and each specimen was sonicated for 20 min. Replicate aliquots of resultant suspensions were plated at dilutions at 37 degrees C for 48 h. The number of colony-forming units (CFU) was counted and expressed as log (CFU+1)/mL and analyzed statistically with alpha=.05. Results: The results showed that 25% PTBAEMA completely inhibited S. aureus and S. mutans biofilm formation. A significant reduction of log (CFU+1)/mL in count of S. aureus (control: 7.9 +/- 0.8A; 10%: 3.8 +/- 3.3B) and S. mutans (control: 7.5 +/- 0.7A; 10%: 5.1 +/- 2.7B) was observed for the group containing 10% PTBAEMA (Mann-Whitney, p < 0.05). For C. albicans, differences were not significant among the groups (control: 6.6 +/- 0.2A; 10%: 6.6 +/- 0.4A; 25%: 6.4 +/- 0.1A), (Kruskal-Wallis, p>0.05, P=0.079). Conclusions: Acrylic resin combined with 10 and 25% of PTBAEMA showed significant antimicrobial activity against S. aureus and S. mutans biofilm, but it was inactive against the C. albicans biofilm.
Issue Date: 
Journal of Applied Oral Science. Bauru-sp: Univ São Paulo Fac Odontologia Bauru, v. 20, n. 6, p. 643-648, 2012.
Time Duration: 
Universidade de São Paulo (USP), Faculdade de Odontologia de Bauru
  • Acrylic resins
  • Biofilms
  • Polymers
  • Dental materials
Access Rights: 
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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