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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/17432
Título: 
Intestinal anti-inflammatory activity of paepalantine, an isocoumarin isolated from the capitula of Paepalanthus bromelioides, in the trinitrobenzenesulphonic acid model of rat colitis
Autor(es): 
Instituição: 
  • Univ Granada
  • Universidade Estadual Paulista (UNESP)
  • Univ Complutense Madrid
ISSN: 
0032-0943
Resumo: 
The preventative intestinal anti-inflammatory activity of paepalantine, an isocoumarin isolated from the capitula of Paepalarithus bromelioides, was tested in the trinitrobenzenesulphonic acid (TNBS) model of rat colitis. This was performed in two different experimental settings, i. e. when the colonic mucosa is intact or when the mucosa is in process of recovery after an initial insult. The results obtained revealed that the paepalantine pretreatment, at doses of 5 and 10 mg/kg, significantly attenuated the colonic damage induced by TNBS in both situations, as it was evidenced both histologically and biochemically. This beneficial effect was associated with an improvement in the colonic oxidative status, since paepalantine prevented the glutathione depletion that occurred as a consequence of the colonic inflammation. In addition, the intestinal anti-inflammatory effect exerted by this isocoumarin was associated with an inhibition of colonic nitric oxide activity, which is upregulated as a consequence of the inflammatory process. In conclusion, the preventative effect exerted by paepalantine in the TNBS model of rat colitis is probably related with its antioxidant properties.
Data de publicação: 
1-Abr-2004
Citação: 
Planta Medica. Stuttgart: Georg Thieme Verlag Kg, v. 70, n. 4, p. 315-320, 2004.
Duração: 
315-320
Publicador: 
Georg Thieme Verlag Kg
Palavras-chaves: 
  • paepalantine
  • isocoumarin
  • capitula of Paepalanthus bromelioides
  • eriocaulaceae
  • antioxidant activity
  • rat colitis
  • TNBS
Fonte: 
http://dx.doi.org/10.1055/s-2004-818942
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/17432
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