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- Atrophic Cardiac Remodeling Induced by Taurine Deficiency in Wistar Rats
- Pansani, Mariele Castilho
- Gaiolla, Paula Schmidt Azevedo
- Murino Rafacho, Bruna Paola
- Minicucci, Marcos Ferreira
- Chiuso-Minicucci, Fernanda
- Zorzella-Pezavento, Sofia Goncalves
- Marchini, Julio Sergio
- Padovan, Gilberto Joao
- Fernandes, Ana Angelica Henrique
- Matsubara, Beatriz Bojikian
- Matsubara, Luiz Shiguero
- Zornoff, Leonardo Antonio Mamede
- Paiva, Sergio Alberto Rupp de
- Universidade Estadual Paulista (UNESP)
- Universidade de São Paulo (USP)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
- Faculdade de Medicina de Botucatu - UNESP
- Introduction: Micronutrient deficiency is observed in heart failure patients. Taurine, for example, represents 50% of total free amino acids in the heart, and in vivo studies have linked taurine deficiency with cardiomyopathy.Methods: Thirty-four male Wistar rats (body weight = 100 g) were weighed and randomly assigned to one of two groups: Control (C) or taurine-deficient (T (-)). Beta-alanine at a concentration of 3% was added to the animals' water to induce taurine deficiency in the T (-) group. on day 30, the rats were individually submitted to echocardiography; morphometrical and histopathological evaluation and metalloproteinase activity, oxidative stress and inflammation evaluation were performed. Tissue samples were collected to determine the taurine concentration in the heart.Results: Taurine deficiency led to decreases in: ventricular wall thickness, left ventricle dry weight, myocyte sectional area, left ventricle posterior wall thickness and ventricular geometry. With regard to heart function, the velocity of the A wave, the ratio between the E and A wave, the ejection fraction, fractional shortening and cardiac output values were decreased in T () rats, suggesting abnormal diastolic and systolic function. Increased fibrosis, inflammation and increased activation of metalloproteinases were not observed. Oxidative stress was increased in deficient animals.Conclusions: These data suggest that taurine deficiency promotes structural and functional cardiac alterations with unique characteristics.
- Plos One. San Francisco: Public Library Science, v. 7, n. 7, p. 6, 2012.
- Public Library Science
- Acesso aberto
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