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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/184
Título: 
Host-guest system of 4-nerolidylcatechol in 2-hydroxypropyl-beta-cyclodextrin: preparation, characterization and molecular modeling
Autor(es): 
Instituição: 
  • Universidade Federal de Goiás (UFG)
  • Universidade Estadual Paulista (UNESP)
  • Universidade de Brasília (UnB)
  • Universidade de São Paulo (USP)
ISSN: 
0923-0750
Financiador: 
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
  • SECTEC-GO
Resumo: 
The interaction of 4-nerolidylcatechol (4-NRC), a potent antioxidant agent, and 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was investigated by the solubility method using Fourier transform infrared (FTIR) methods in addition to UV-Vis, (1)H-nuclear magnetic resonance (NMR) spectroscopy and molecular modeling. The inclusion complexes were prepared using grinding, kneading and freeze-drying methods. According to phase solubility studies in water a B(S)-type diagram was found, displaying a stoichiometry complexation of 2:1 (drug:host) and stability constant of 6494 +/- A 837 M(-1). Stoichiometry was established by the UV spectrophotometer using Job's plot method and, also confirmed by molecular modeling. Data from (1)H-NMR, and FTIR, experiments also provided formation evidence of an inclusion complex between 4-NRC and HP-beta-CD. 4-NRC complexation indeed led to higher drug solubility and stability which could probably be useful to improve its biological properties and make it available to oral administration and topical formulations.
Data de publicação: 
1-Jun-2009
Citação: 
Journal of Inclusion Phenomena and Macrocyclic Chemistry. Dordrecht: Springer, v. 64, n. 1-2, p. 23-35, 2009.
Duração: 
23-35
Publicador: 
Springer
Palavras-chaves: 
  • 4-Nerolidylcatechol
  • 2-Hydroxypropyl-beta-cyclodextrin
  • Inclusion complex
  • (1)H-NMR and molecular dynamics
Fonte: 
http://dx.doi.org/10.1007/s10847-009-9532-y
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/184
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