Please use this identifier to cite or link to this item:
- Molecular models for shikimate pathway enzymes of Xylella fastidiosa
- Universidade Estadual Paulista (UNESP)
- Universidade Federal do Rio Grande do Sul (UFRGS)
- Instituto Butantan
- Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
- The Xylella fastidiosa is a bacterium that is the cause of citrus variegated chlorosis (CVC). The shikimate pathway is of pivotal importance for production of a plethora of aromatic compounds in plants, bacteria, and fungi. Putative structural differences in the enzymes from the shikimate pathway, between the proteins of bacterial origin and those of plants, could be used for the development of a drug for the control of CVC. However, inhibitors for shikimate pathway enzymes should have high specificity for X. fastidiosa enzymes, since they are also present in plants. In order to pave the way for structural and functional efforts towards antimicrobial agent development, here we describe the molecular modeling of seven enzymes of the shikimate pathway of X. fastidiosa. The structural models of shikimate pathway enzymes, complexed with inhibitors, strongly indicate that the previously identified inhibitors may also inhibit the X. fastidiosa enzymes. (C) 2004 Elsevier B.V. All rights reserved.
- Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc. Elsevier B.V., v. 320, n. 3, p. 979-991, 2004.
- Elsevier B.V.
- shikimate pathway
- structural bioinformatics
- drug design
- Xylella fastidiosa
- Acesso restrito
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.