Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/20087
- Title:
- Evaluating methods for the isolation of marine-derived fungal strains and production of bioactive secondary metabolites
- Kossuga, Miriam H.
- Romminger, Stelamar
- Xavier, Camila
- Milanetto, Marília C.
- Valle, Milene Z. do
- Pimenta, Eli F.
- Morais, Raquel P.
- Carvalho, Erica de
- Mizuno, Carolina M.
- Coradello, Luís Fernando C.
- Barroso, Vinícius de M.
- Vacondio, Bruna
- Javaroti, Darci C. D.
- Seleghim, Mirna H. R.
- Cavalcanti, Bruno C.
- Pessoa, Claudia
- Moraes, Manoel O.
- Lima, Bruna A.
- Gonçalves, Reginaldo
- Bonugli-Santos, Rafaella C.
- Sette, Lara D.
- Berlinck, Roberto G. S.
- Universidade de São Paulo (USP)
- Universidade Federal de São Carlos (UFSCar)
- Universidade Federal do Ceará (UFC)
- Universidade Estadual de Campinas (UNICAMP)
- Universidade Estadual Paulista (UNESP)
- 0102-695X
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- FAPESP: 10/50190-2
- FAPESP: 05/60175-2
- In the present investigation we evaluate methods for the isolation and growth of marine-derived fungal strains in artificial media for the production of secondary metabolites. Inoculation of marine macroorganisms fragments in Petri dishes proved to be the most convenient procedure for the isolation of the largest number of strains. Among the growth media used, 3% malt extract showed the best result for strains isolation and growth, and yielded the largest number of strains from marine macroorganisms. The percentage of strains isolated using each of the growth media which yielded cytotoxic and/or antibiotic extracts was in the range of 23-35%, regardless of the growth media used. Further investigation of extracts obtained from different marine-derived fungal strains yielded several bioactive secondary metabolites, among which (E)-4-methoxy-5-(3-methoxybut-1-enyl)-6-methyl-2H-pyran-2-one is a new metabolite isolated from the Penicillium paxilli strain Ma(G)K.
- 1-Apr-2012
- Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 22, n. 2, p. 257-267, 2012.
- 257-267
- Sociedade Brasileira de Farmacognosia
- antimicrobial
- biological screening
- cytotoxic
- marine-derived fungi
- http://dx.doi.org/10.1590/S0102-695X2011005000222
- http://hdl.handle.net/11449/20087
- Acesso aberto
- outro
- http://repositorio.unesp.br/handle/11449/20087 Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp
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