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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/20761
Título: 
Differential coronary resistance microvessel remodeling between type 1 and type 2 diabetic mice: Impact of exercise training
Autor(es): 
Instituição: 
  • Nationwide Childrens Hosp
  • Ohio State Univ
  • Universidade Estadual Paulista (UNESP)
  • Louisiana State Univ
ISSN: 
1537-1891
Financiador: 
  • National Institutes of Health (NIH)
  • Heart Center at Nationwide Children's Hospital
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento: 
  • NIH: R01-HL056046
  • NIH: T32HL098039
Resumo: 
The goals of the present study were to compare coronary resistance microvessel (CRM) remodeling between type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) mice, and to determine the impact of aerobic exercise training on CRM remodeling in diabetes. Eight week old male mice were divided into T1DM: control sedentary (Control-SD), T1DM sedentary (T1DM-SD) induced by streptozotocin, and T1DM exercise trained (T1DM-TR); T2DM: control sedentary (Db/db-SD), T2DM sedentary (db/db-SD), and T2DM trained (db/db-TR). Aerobic exercise training (TR) was performed on a mouse treadmill for 8 weeks. CRMs were isolated and mounted on a pressure myograph to measure and record vascular remodeling and mechanics. CRM diameters, wall thickness, stress-strain, incremental modulus remained unchanged in 11 DM-SD mice compared to control, and exercise training showed no effect. In contrast, CRMs isolated from db/db-SD mice exhibited decreased luminal diameter with thicker microvascular walls, which significantly increased the wall:lumen ratio (Db/db-SD: 5.8 +/- 0.3 vs. db/db-SD: 8.9 +/- 0.7, p<0.001). Compared to db/db-SD mice, coronary arterioles isolated from db/db-TR mice had similar internal diameter and wall thickness, while wall:lumen ratio (6.8 +/- 0.2, p<0.05) and growth index (db/db-SD: 16.2 vs. db/db-TR: 4.3, % over Db/db) were reduced. These data show that CRMs undergo adverse inward hypertrophic remodeling only in T2DM, but not T1DM, and that aerobic exercise training can partially mitigate this process. (C) 2012 Elsevier B.V. All rights reserved.
Data de publicação: 
1-Nov-2012
Citação: 
Vascular Pharmacology. New York: Elsevier B.V., v. 57, n. 5-6, p. 187-193, 2012.
Duração: 
187-193
Publicador: 
Elsevier B.V.
Palavras-chaves: 
  • Coronary remodeling
  • Exercise
  • Vascular
  • Type 2 diabetes
  • Type 1 diabetes
  • Myocardial infarction
Fonte: 
http://dx.doi.org/10.1016/j.vph.2012.07.007
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/20761
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