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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/22607
Título: 
Homogenous amniotic membrane as a biological dressing for oral mucositis in rats: Histomorphometric analysis
Autor(es): 
Instituição: 
  • Universidade Estadual Paulista (UNESP)
  • Assoc ProSaúde Pacientes Necessidades Especiais A
ISSN: 
0003-9969
Financiador: 
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento: 
FAPESP: 04/04447-0
Resumo: 
Objective: oral mucositis is a frequent and significant side effect of chemotherapy and/or radiation therapy. The purpose of this study was to evaluate the effects of the homogenous amniotic membrane (HAM) as a biological dressing for oral mucositis induced by 5-fluorouracil (5-FU) in the labial fornix region of inferior incisors in rats.Methods: Sixty rats were divided into three groups: control (50% acetic acid), 5-FU (50% acetic acid and 5-fluorouracil-induced oral mucositis) and 5-FU + HAM (50% acetic acid and 5fluorouracil-induced oral mucositis, and treated with HAM). Histological analyses were done 3, 7, 14 and 21 days after applying the acetic acid.Results: HAM showed not only no signs of rejection as well as an excellent tissue adherence to the ulcerated surface. Histomorphometric analysis indicated a lower quantity of inflammatory cells in the 5-FU + HAM group in all periods when compared to the other groups and there was a statistically significant difference in the 3- and 7-day periods (P < 0.001).Conclusions: The results of this study suggest that HAM was biocompatible with great adhesive power to the ulcerated surface, accelerated the healing process and exhibited anti-inflammatory activity. Further studies should be done to investigate the potential benefits of this material in clinical trials. HAM could lead to improved results as a biological dressing in treatment and management of oral mucositis in patients submitted to chemotherapy and/or radiation therapy. (C) 2008 Elsevier Ltd. All rights reserved.
Data de publicação: 
1-Dez-2008
Citação: 
Archives of Oral Biology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 53, n. 12, p. 1163-1171, 2008.
Duração: 
1163-1171
Publicador: 
Pergamon-Elsevier B.V. Ltd
Palavras-chaves: 
  • Homogenous amniotic membrane
  • Biological dressing
  • Oral mucositis
  • Healing process
  • 5-Fluorouracil
Fonte: 
http://dx.doi.org/10.1016/j.archoralbio.2008.07.003
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/22607
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