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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/22649
Title: 
Comparative analysis of cell proliferation ratio in oral lichen planus, epithelial dysplasia and oral squamous cell carcinoma
Author(s): 
Institution: 
Universidade Estadual Paulista (UNESP)
ISSN: 
1698-4447
Abstract: 
Background: Although oral lichen planus has been classified by the World Health Organization (WHO) as a potentially malignant disorder, such classification is still the target of much controversy. Aim: To evaluate the cell proliferation rate in oral lichen planus, comparing it to the rate observed in epithelial dysplasia and oral squamous cell carcinoma, aiming at indications which might indicate the potential for malignant transformation. Material and Methods: Twenty-four cases of each lesion were submitted to the streptoavidin-biotin and AgNOR technique to evaluate the immunohistochemical expression of PCNA and the mean NORs/ nucleus, respectively. Results: Positivity for PCNA was observed in 58.33% of oral lichen planus cases, 83.33% of epithelial dysplasia cases and 91.67% of oral squamous cell carcinoma cases. Chi-squared test showed that the number of positive cases for PCNA was significantly lower in oral lichen planus than in oral squamous cell carcinoma (p<0.05). No significant statistical difference between oral lichen planus and epithelial dysplasia (p>0.05) and between the epithelial dysplasia and oral squamous cell carcinoma (p>0.05) was observed. The mean NORs/ nucleus in oral lichen planus, epithelial dysplasia and oral squamous cell carcinoma were 1.74 +/- 0.32, 2.42 +/- 0.62 e 2.41 +/- 0.61, respectively. Variance analysis (ANOVA) revealed significant statistical difference between oral lichen planus and the other studied lesions (p<0.05). Conclusion: Oral lichen planus cell proliferation rate was less than in oral epithelial dysplasia and oral squamous cell carcinoma which might explain the lower malignant transformation rate.
Issue Date: 
1-Nov-2009
Citation: 
Medicina Oral Patologia Oral Y Cirugia Bucal. Valencia: Medicina Oral S L, v. 14, n. 11, p. E563-E567, 2009.
Time Duration: 
E563-E567
Publisher: 
Medicina Oral S L
Keywords: 
  • Oral lichen planus
  • epithelial dysplasia
  • oral squamous cell carcinoma
  • immunohistochemistry
  • Agnor
Source: 
http://dx.doi.org/10.4317/medoral.14.e563
URI: 
Access Rights: 
Acesso aberto
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/22649
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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