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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/22665
Title: 
Influence of chronic alcoholism and oestrogen deficiency on the variation of stoichiometry of hydroxyapatite within alveolar bone crest of rats
Author(s): 
Institution: 
  • Universidade Estadual Paulista (UNESP)
  • Univ Vale Paraiba Univ
  • Univ Taubate UNITAU
  • Univ Vale Paraiba
  • Universidade de São Paulo (USP)
ISSN: 
0003-9969
Sponsorship: 
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Abstract: 
Objective: Previous findings suggest that chronic alcoholism and oestrogenic deficiency may affect bones in general (including alveolar bone) and increase individuals' susceptibility to the development of periodontal disease. The aim of this study was to assess possible alterations in the chemical composition of alveolar bone in rats subjected to chronic alcoholism, oestrogen deficiency or both.Design: Fifty-four rats were initially divided into two groups: ovariectomized (Ovx), and Sham operated (Sham). A month after surgery, the groups were sub-divided and received the following dietary intervention for eight weeks: 20% alcohol, isocaloric diet and ad libitum diet. Samples of the mandible, in the alveolar bone crest region, were analyzed to verify possible changes in the stoichiometric composition of bone hydroxyapatite, by measuring the relationship between the concentration of calcium and phosphorus (Ca/P ratios), using micro X-ray fluorescence spectrometry.Results: The ad libitum groups presented the highest average values of Ca/P ratios, while the groups with dietary restrictions presented the smallest average values. The Ovx ad libitum group presented the highest values of Ca/P ratios (2.03 +/- 0.04). However, these values were not considered statistically different (p > 0.05) from the Sham ad libitum group (2.01 +/- 0.01). The Ovx alcohol group presented lower values for Ca/P ratios (1.92 +/- 0.06), being the only group statistically different (p < 0.001) from the Sham ad libitum group. Potential confounding variables are discussed.Conclusion: Ovariectomy associated with alcohol consumption at 20% significantly changed the stoichiometry composition of hydroxyapatite in the alveolar bone crest, leading to a reduction in Ca/P ratios. (c) 2012 Elsevier Ltd. All rights reserved.
Issue Date: 
1-Oct-2012
Citation: 
Archives of Oral Biology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 57, n. 10, p. 1385-1394, 2012.
Time Duration: 
1385-1394
Publisher: 
Pergamon-Elsevier B.V. Ltd
Keywords: 
  • Alcoholism
  • Ovariectomy
  • Periodontium
  • Fluorescence spectrometry
  • Calcium
  • Phosphorous
Source: 
http://dx.doi.org/10.1016/j.archoralbio.2012.04.011
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/22665
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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