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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/31567
Título: 
AIDS-related lymphoma in Brazil - Histopathology, immunophenotype, and association with Epstein-Barr virus
Autor(es): 
Instituição: 
  • Universidade Estadual Paulista (UNESP)
  • Universidade de São Paulo (USP)
  • Universidade Federal da Bahia (UFBA)
  • CITY HOPE NATL MED CTR
ISSN: 
0002-9173
Resumo: 
The occurrence of malignant lymphoma is an increasingly important cause of morbidity and mortality in AIDS patients. The incidence of AIDS-related lymphoma in some developing countries such as Brazil is increasing as the survival of HIV infection has improved. Although there is a clear association between several types of immunodeficiency related lymphomas and Epstein-Barr virus (EBV), the association of EBV infection in AIDS-related lymphoma in Brazil, where the incidence of AIDS is high, is unknown. Formalin-fixed, paraffin-embedded tissue from 24 cases of AIDS-related lymphoma in Brazil were analyzed for morphologic classification, immunophenotype, and EBV association using in situ hybridization studies with an EBV-EBER1 biotinylated probe. Twenty cases of AIDS-related lymphoma were classified as non-Hodgkin's lymphoma and four cases were Hodgkin's disease. Eleven non-Hodgkin's lymphomas were classified as diffuse large cell type, five cases were small non-cleaved cell, Burkitt-type, and four cases were large cell immunoblastic non-Hodgkin's lymphoma. Eighteen cases were of B-cell phenotype; one was a T-cell lymphoma, and one was classified as null. Epstein-Barr virus (EBV) was demonstrated in the majority of tumor cells of 11 of 20 (55%) of the cases non-Hodgkin's lymphomas and in 3 of 4 (75%) cases of Hodgkin's disease. AIDS-related lymphomas in Brazil are usually of large cell/immunoblastic type, but Hodgkin's disease is also seen. Both non-Hodgkin's lymphoma and Hodgkin's disease are often associated with EBV infection. The non-Hodgkin's lymphoma is predominantly of B-cell phenotype.
Data de publicação: 
1-Fev-1996
Citação: 
American Journal of Clinical Pathology. Philadelphia: Lippincott-raven Publ, v. 105, n. 2, p. 230-237, 1996.
Duração: 
230-237
Publicador: 
Lippincott-raven Publ
Palavras-chaves: 
  • AIDS
  • HIV
  • EBV
  • immunohistochemistry
  • lymphoma
  • Hodgkin's disease
  • in situ hybridization
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/31567
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