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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/34065
Title: 
Anxiolytic effects of erythrinian alkaloids from Erythrina mulungu
Author(s): 
Institution: 
  • Universidade Estadual Paulista (UNESP)
  • Univ Ribeirao Preto
  • Universidade de São Paulo (USP)
  • Universidade Federal do Rio Grande do Sul (UFRGS)
ISSN: 
0163-3864
Abstract: 
One new erythrinian alkaloid derivative, (+)-11 alpha-hydroxyerythravine (1), and the known (+)-erythravine (2) and (+)-alpha-hydroxyerysotrine (3) were isolated from the flowers of Erythrina mulungu. Their structures were determined by spectroscopic/spectrometric data interpretation of H-1, C-13, and 2D NMR and MS experiments. The relative configuration was established by NOESY analysis, while the conformation adopted by these molecules was evaluated through molecular modeling studies and coupling constants obtained by NMR analysis. Furthermore, the anxiolytic effects of the E. mulungu aqueous alcoholic crude extract and of the purified alkaloids were evaluated using the elevated T-maze test.
Issue Date: 
1-Jan-2007
Citation: 
Journal of Natural Products. Washington: Amer Chemical Soc, v. 70, n. 1, p. 48-53, 2007.
Time Duration: 
48-53
Publisher: 
Amer Chemical Soc
Source: 
http://dx.doi.org/10.1021/np060254j
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/34065
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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