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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/34573
Título: 
Stereological study of acinar growth in the rat parotid gland induced by isoproterenol
Autor(es): 
Instituição: 
  • Universidade Federal do Rio Grande do Norte (UFRN)
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
ISSN: 
0003-9969
Resumo: 
The growth of the rat parotid gland induced by daily treatment with isoproterenol (IPR) for 2 weeks was investigated by stereological methods applied to light microscopy. After 7 days of treatment, the glandular mass presented a 286% growth, with the first 3 days being the period of greatest growth. Total acinar volume exhibited a 363% increase during the period from 0 to 7 days, while acinar-cell volume presented a 468% growth from 0 to 5 days of treatment. on the other hand, total acinar-cell number did not increase during the study period. Thus, under the conditions used, IPR-stimulated gland growth wits essentially hypertrophic. However, a significant increase in the number of bipolar and multipolar mitoses was also observed, especially on the third and fifth days of treatment. As no increase in acinar-cell number occurred during growth, the presence of these mitoses suggests that cell death occurred during gland growth. on this basis, bipolar mitoses may occur to replace cells that probably degenerated during treatment, whereas multipolar mitoses may lead to the occurrence of polyploidy. (C) 1997 Elsevier B.V. Ltd.
Data de publicação: 
1-Mai-1997
Citação: 
Archives of Oral Biology. Oxford: Pergamon-Elsevier B.V., v. 42, n. 5, p. 333-338, 1997.
Duração: 
333-338
Publicador: 
Elsevier B.V.
Palavras-chaves: 
  • isoproterenol
  • hypertrophy
  • hyperplasia
  • acini
  • salivary gland
  • parotid gland
  • stereology
Fonte: 
http://dx.doi.org/10.1016/S0003-9969(97)00025-3
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/34573
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